Bone Graft Substitutes: Current Concepts and Future Expectations
Bone Graft Substitutes: Current Concepts and Future Expectations
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DOI：
10.1016/j.jhsa.2018.10.032
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发表时间：
2019-06-01
影响因子：
1.9
通讯作者：
Chhabra, A. Bobby
中科院分区：
文献类型：
--
作者：
Lobb, David C.;DeGeorge, Brent R., Jr.;Chhabra, A. Bobby
由于其骨诱导和骨传导特性以及成骨细胞的存在，新鲜采集的自体骨移植物是自体骨不足的骨骼重建的金标准。尽管这些特征难以复制，但工程化的市售骨移植替代品旨在实现可比的骨再生特征。这项工作使读者对创伤或肿瘤手术后上肢骨缺损重建的骨移植替代物的主要类别有所了解。我们就骨移植替代物的作用机制、优缺点、适应症和禁忌症进行综述。我们提供了临床使用的骨移植替代品的例子，并概述了比较成本。我们还描述了重建手术的这一特定方面的未来方向，重点是生物活性玻璃的作用。版权所有（C）2019美国手外科学会。All rights reserved.
Owing to its osteoinductive and osteoconductive properties and the presence of osteogenic cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction where there is inadequate native bone. Whereas these characteristics are difficult to replicate, engineered, commercially available bone graft substitutes aim to achieve a comparable osseoregenerative profile. This work furnishes the reader with an understanding of the pre-dominant classes of bone graft substitutes available for reconstruction of upper extremity bone defects following trauma or oncological surgery. We review bone graft substitutes with respect to their mechanisms of action, their advantages and disadvantages, and their indications and contraindications. We provide examples of bone graft substitutes in clinical use and outline comparative costs. We also describe the future directions for this specific aspect of reconstructive surgery with a focus on the role of bioactive glass. Copyright (C) 2019 by the American Society for Surgery of the Hand. All rights reserved.