A Prospective Study on the Safety and Efficacy of Vascularized Lymph Node Transplant.
A Prospective Study on the Safety and Efficacy of Vascularized Lymph Node Transplant.
复制标题
一项关于血管化淋巴结移植的安全性和有效性的前瞻性研究。
DOI：
10.1097/sla.0000000000005591
复制
发表时间：
2022-10-01
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
作者：
While vascularized lymph node transplant (VLNT) has gained popularity, there is a lack of prospective long-term studies and standardized outcomes. The purpose of this study was to evaluate the safety and efficacy of VLNT using all available outcome measures. This was a prospective study on all consecutive patients who underwent VLNT. Outcomes were assessed with two patient-reported outcome metrics, limb volume, bioimpedance, need for compression, and incidence of cellulitis. There were 89 patients with the following donor sites: omentum (73%), axilla (13%), supraclavicular (7%), groin (3.5%). Mean follow-up was 23.7 ±12 months. There was a significant improvement at 2 years post-op across all outcome measures: 28.4% improvement in the Lymphedema Life Impact Scale (LLIS), 20% average reduction in limb volume, 27.5% improvement in bioimpedance score, 93% reduction in cellulitis, and 34% of patients no longer required compression. Complications were transient and low without any donor site lymphedema. VLNT is a safe and effective treatment for lymphedema with significant benefits fully manifesting at 2 years post-op. Omentum does not have any donor site lymphedema risk making it an attractive first choice. Vascularized lymph node transplant provides satisfactory reduction in limb volume, bioimpedance, and improved quality of life. Vascularized omentum transplant is a reliable alternative to peripheral VLNT with no risk of donor site lymphedema and particularly significant impact in reducing the incidence of cellulitis.
