Neuronal Ensemble Synchrony during Human Focal Seizures
Neuronal Ensemble Synchrony during Human Focal Seizures
复制标题
DOI：
10.1523/jneurosci.4567-13.2014
复制
发表时间：
2014-07-23
影响因子：
5.3
通讯作者：
Cash, Sydney S.
中科院分区：
文献类型：
--
作者：
Truccolo, Wilson;Ahmed, Omar J.;Cash, Sydney S.
癫痫发作的典型特征是神经活动的超同步表达，然而人类癫痫发作期间神经元尖峰（动作电位）的真正同步程度仍然是一个基本问题。我们量化了药理学上难治性癫痫患者癫痫发作期间新皮质神经元群中峰同步的时间精度。分析了两种癫痫发作类型：以持续γ（类似于40-60 Hz）局部场电位（LFP）振荡或以尖波复合体（SWCs，类似于3 Hz）为特征的癫痫发作。罚款(
Seizures are classically characterized as the expression of hypersynchronous neural activity, yet the true degree of synchrony in neuronal spiking (action potentials) during human seizures remains a fundamental question. We quantified the temporal precision of spike synchrony in ensembles of neocortical neurons during seizures in people with pharmacologically intractable epilepsy. Two seizure types were analyzed: those characterized by sustained gamma (similar to 40-60 Hz) local field potential (LFP) oscillations or by spike-wave complexes (SWCs; similar to 3 Hz). Fine (