Multiple sclerosis as a generalized CNS disease - comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS
Multiple sclerosis as a generalized CNS disease - comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS
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DOI：
10.1016/j.jneuroim.2004.03.011
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发表时间：
2004-07-01
影响因子：
3.3
通讯作者：
Leppert, D
中科院分区：
文献类型：
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作者：
Lindberg, RLP;De Groot, CJA;Leppert, D
我们使用微阵列比较了继发性进行性多发性硬化症（MS）患者与死于非神经系统疾病的对照组的脑尸检样本中活动性病变和供体匹配的正常外观白色物质（NAWM）的基因表达谱。其中123个基因在病变组织中有差异表达，47个基因在NAWM（MS）组织中有差异表达。与NAWM（MS）不同的是，与免疫球蛋白合成和神经胶质细胞分化相关的基因表达更高，而细胞免疫反应元件在两个组织区室中同样失调。目前的研究结果提供了分子证据的一个连续的功能失调的稳态和病变和NAWM（MS）之间的炎症变化，并支持MS发病机制是一个广义的过程，涉及整个中枢神经系统的概念。(C)2004 Elsevier B.V.保留所有权利。
We used microarrays to compare the gene expression profile in active lesions and donor-matched normal appearing white matter (NAWM) from brain autopsy samples of patients with secondary progressive multiple sclerosis (MS) with that from controls who died from non-neurological diseases. The 123 genes in lesions, and 47 genes in NAWM(MS) were differentially expressed. Lesions distinguished from NAWM(MS) by a higher expression of genes related to immunoglobulin synthesis and neuroglial differentiation, while cellular immune response elements were equally dysregulated in both tissue compartments. Current results provide molecular evidence of a continuum of dysfunctional homeostasis and inflammatory changes between lesions and NAWM(MS), and support the concept of MS pathogenesis being a generalised process that involves the entire CNS. (C) 2004 Elsevier B.V. All rights reserved.