Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome
Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome
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DOI：
10.1111/j.1600-0609.2006.00631.x
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发表时间：
2006-06-01
影响因子：
3.1
通讯作者：
Moriwaki, H
中科院分区：
文献类型：
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作者：
Kojima, Y;Tsurumi, H;Moriwaki, H
近年来，弥漫性大B细胞淋巴瘤（DLBCL）通过DNA微阵列分析被分为生发中心B细胞样（GC）型、活化B细胞样（ABC）型和3型。后两种类型可以统称为非GC（NGC）类型。从预后的角度来看，与NGC型相比，GC型具有良好的临床结局。Fas蛋白通过与Fas配体（FasL）结合而诱导淋巴细胞凋亡，并且逃避这种凋亡被认为导致细胞的恶性转化和淋巴瘤的不受限制的生长。我们提出Fas/FasL表达可能与胃癌型DLBCL的生存期有关的假说，并对69例DLBCL患者进行了CD 10、Bcl-6、MUM 1、Fas和FasL的免疫组化检测。这些淋巴瘤被分为GC型（CD 10或Bcl-6阳性，MUM 1阴性）或NGC型。GC型总生存率高于NGC型（P = 0.0723）。在上述指标中，CD 10阳性是影响DLBCL患者总生存率的最重要的预后因素（P < 0.05）。在胃癌中，Fas和FasL的表达与良好的总生存率显著相关（Fas：P < 0.005; FasL：P < 0.05）。Fas或FasL的表达可能有助于改善DLBCL的预后。
In recent years, diffuse large B-cell lymphoma (DLBCL) has been classified by DNA microarray analysis into the germinal center B-cell-like (GC) type, the activated B-cell-like (ABC) type and type 3. The latter two types can be collectively categorized as the non-GC (NGC) type. From the prognostic perspective, the GC type has a favorable clinical outcome when compared with the NGC type. The protein Fas induces apoptosis of lymphocytes by binding with the Fas ligand (FasL), and escape from such apoptosis is considered to lead to malignant transformation of the cells and unrestricted growth of lymphoma. We proposed a hypothesis that Fas/FasL expression could be possibly related with a better survival of GC type DLBCL and evaluated 69 DLBCL cases immunohistochemically with CD10, Bcl-6, MUM1, Fas and FasL. These lymphomas were classified as GC type (positive for CD10 or Bcl-6 and negative for MUM1) or NGC type. The GC type had a better overall survival rate than the NGC type (P = 0.0723). Among markers as given above, positive CD10 was the most significant prognostic factor for overall survival in total DLBCL (P < 0.05). In the GC type, Fas and FasL expressions were significantly associated with a favorable overall survival (Fas: P < 0.005; FasL: P < 0.05). Hence, Fas or FasL expression might contribute to a better prognosis of this type of DLBCL.