Absorption Characteristics of Model Drugs from the Gastric Serosal Surface in Rats
Absorption Characteristics of Model Drugs from the Gastric Serosal Surface in Rats
复制标题
模型药物在大鼠胃浆膜表面的吸收特性
DOI：
10.1211/146080899128734226
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Sakaeda
中科院分区：
文献类型：
--
作者：
T. Mukai;Atsuko Tsurumaru;K. Mera;K. Nishida;J. Nakamura;H. Sasaki;T. Sakaeda
用圆柱形玻璃吸收池研究了酚红在大鼠胃浆膜表面的吸收特性。
0.3、1和3 mg酚红在6 h内的吸收率无显著差异，表明胃浆膜表面的线性吸收。当应用酚红和牛血清白蛋白时，药物吸收随着蛋白浓度的增加而降低，表明蛋白结合是控制药物从胃浆膜表面吸收的重要因素。
这些发现可能有助于开发新的胃给药途径。
The in-vivo absorption characteristics of phenol red were studied after application to the rat gastric serosal surface, using a cylindrical glass cell.
There was no significant difference between absorption ratios of 0.3, 1 and 3 mg phenol red in 6 h, suggesting linear absorption from the gastric serosal surface. When phenol red and bovine serum albumin were applied, drug absorption decreased with increasing protein concentration, indicating that protein binding is an important factor controlling drug absorption from the gastric serosal surface.
These findings may be useful in the development of novel administration routes for drug delivery to the stomach.