Investigating the Association Between Early Life Parental Care and Stress Responsivity in Adulthood
Investigating the Association Between Early Life Parental Care and Stress Responsivity in Adulthood
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DOI：
10.1080/87565641.2010.494752
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发表时间：
2010-01-01
影响因子：
1.5
通讯作者：
Pruessner, Jens C.
中科院分区：
文献类型：
--
作者：
Engert, Veronika;Buss, Claudia;Pruessner, Jens C.
我们探讨了37名老年志愿者的早期生活经验，内分泌调节，心理健康和海马完整性之间的关系。具体来说，神经发育和心理调解模型进行了测试：回顾性的早期生活的父母照顾假设影响海马的完整性和自尊的发展。反过来，海马体积（通过调节下丘脑-垂体-肾上腺轴负反馈）和自尊（通过调节应激脆弱性）被认为会影响皮质醇应激反应。结果支持双中介模型。我们建议，早期生活的父母照顾影响一个人的大脑发育和个性，从而有助于塑造神经内分泌应激反应。
We explored the associations between early life experience, endocrine regulation, psychological health, and hippocampal integrity in 37 elderly volunteers. Specifically, a neurodevelopmental and psychological mediation model was tested: Retrospective early life parental care was hypothesized to influence hippocampal integrity and the development of self-esteem. In turn, hippocampal volume (via modulation of hypothalamic-pituitary-adrenal axis negative feedback) and self-esteem (via modulation of stress vulnerability) were suggested to influence the cortisol stress response. Results supported the two-mediator model. We propose that early life parental care impacts on an individual's developing brain and personality, which consequently contribute to the shaping of neuroendocrine stress responsivity.