Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
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DOI：
10.1186/2045-9912-2-12
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发表时间：
2012
影响因子：
2.9
通讯作者：
Miyakawa S
中科院分区：
文献类型：
--
作者：
Aoki K;Nakao A;Adachi T;Matsui Y;Miyakawa S
短时间剧烈运动期间的肌肉收缩会导致氧化应激，这可能在过度训练症状的发展中发挥作用，包括疲劳增加，导致肌肉微损伤或炎症。最近有人说，氢可以作为抗氧化剂，因此，我们研究了富氢水（HW）对急性运动引起的氧化应激和肌肉疲劳的影响。对10名年龄为20.9 ± 1.3岁的男子足球运动员进行了运动试验和血样采集。以交叉双盲方式对每例受试者进行两次检查;每隔一周给予HW或安慰剂水（PW）。要求受试者在75%最大摄氧量（VO 2）下使用自行车测力计30分钟，然后在100次最大等速膝关节伸展中测量峰值扭矩和肌肉活动。依次测定外周血中的氧化应激标志物和肌酸激酶。尽管急性运动导致PW受试者的血乳酸水平升高，但口服HW可防止剧烈运动期间血乳酸升高。在最大等速伸膝阶段，PW的峰值扭矩显著降低，提示肌肉疲劳，而HW的峰值扭矩在早期阶段没有降低。运动后血液氧化损伤标志物（d-ROM和BAP）或肌酸激酶无显著变化。运动前用富含氢的水进行充分的水合作用可以降低血乳酸水平，改善运动引起的肌肉功能下降。虽然进一步的研究，以阐明确切的机制和好处，需要在更大的一系列研究中证实，这些初步结果可能表明，HW可能是适合运动员的水合作用。
Muscle contraction during short intervals of intense exercise causes oxidative stress, which can play a role in the development of overtraining symptoms, including increased fatigue, resulting in muscle microinjury or inflammation. Recently it has been said that hydrogen can function as antioxidant, so we investigated the effect of hydrogen-rich water (HW) on oxidative stress and muscle fatigue in response to acute exercise. Ten male soccer players aged 20.9 ± 1.3 years old were subjected to exercise tests and blood sampling. Each subject was examined twice in a crossover double-blind manner; they were given either HW or placebo water (PW) for one week intervals. Subjects were requested to use a cycle ergometer at a 75 % maximal oxygen uptake (VO2) for 30 min, followed by measurement of peak torque and muscle activity throughout 100 repetitions of maximal isokinetic knee extension. Oxidative stress markers and creatine kinase in the peripheral blood were sequentially measured. Although acute exercise resulted in an increase in blood lactate levels in the subjects given PW, oral intake of HW prevented an elevation of blood lactate during heavy exercise. Peak torque of PW significantly decreased during maximal isokinetic knee extension, suggesting muscle fatigue, but peak torque of HW didn’t decrease at early phase. There was no significant change in blood oxidative injury markers (d-ROMs and BAP) or creatine kinease after exercise. Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. Although further studies to elucidate the exact mechanisms and the benefits are needed to be confirmed in larger series of studies, these preliminary results may suggest that HW may be suitable hydration for athletes.