REARRANGEMENT OF EPINEPHRINE
REARRANGEMENT OF EPINEPHRINE
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DOI：
10.1038/182311a0
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发表时间：
1958-01-01
期刊：
影响因子：
64.8
通讯作者：
FELLMAN, JH
中科院分区：
文献类型：
--
作者：
FELLMAN, JH
从逻辑上讲，对代谢物的酶促变化的研究始于对其电子构型的性质的了解和对分子化学敏感性的认识。这些信息为研究代谢途径提供了一个合理的途径。当这种方法被应用于邻苯二酚胺代谢降解的研究时，出现了一种有趣的代谢通道的可能性。我想报告肾上腺素和去甲肾上腺素的重排，导致3，4-二羟基苯乙醛的形成。由于该醛是3，4-二羟基苯乙酸乙酯的直接中间体，3，4-二羟基苯乙酸乙酯是去甲肾上腺素与肝脏切片孵育的产物之一，这种重排可能代表了儿茶酚胺进一步生化途径的化学模型。
THE study of the enzymatic alteration of a metabolite logically starts from the knowledge of the nature of its electronic configuration and an appreciation of the chemical susceptibilities of the molecule. Such information provides a rational avenue for an investigation into the metabolic pathway. When this approach was applied in a study of the metabolic degradation of the catechol amines, an interesting possibility for a channel of metabolism emerged. I wish to report a rearrangement of epinephrine and norepinephrine of the pinacol-pinacolone type, leading to the formation of 3, 4-dihydroxyphenylacetaldehyde. Since this aldehyde is a direct intermediate of 3, 4-dihydroxyphenylacetic ac~ d, one of the metabolites which has been reported to be a product from the incubation of norepinephrine with liver slices', this rearrangement may represent a chemical model for a further biochemical pathway of catechol amines.