Current manufacturing processes of drug-eluting sutures
Current manufacturing processes of drug-eluting sutures
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DOI：
10.1080/17425247.2017.1289173
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发表时间：
2017-01-01
影响因子：
6.6
通讯作者：
Jerome, Christine
中科院分区：
文献类型：
--
作者：
Champeau, Mathilde;Thomassin, Jean-Michel;Jerome, Christine
简介：药物洗脱缝线代表了下一代外科缝线，因为它们既能实现其机械功能，又能在植入后在其附近输送药物。这些植入物通过多种制造工艺生产。药物洗脱缝线代表了下一代外科缝线，因为它们既能实现其机械功能，又能在植入后在其附近输送药物。这些植入物通过多种制造工艺生产。两种一般的方法可以遵循：（一）在缝线的制造过程中将API添加到材料中的方法和（二）将API加载到已经制造的suture.Areas的方法：本综述概述了药物洗脱缝线生产的当前制造工艺，并根据药物类型讨论了其优点和缺点。药物洗脱缝线的机械性能和药物递送特性是突出的，因为这些植入物必须满足这两个标准。专家意见：对于有限的药物含量，熔融挤出和静电纺丝是新兴的工艺，因为药物是在缝线制造过程中添加的。有利的是，药物释放曲线可以通过控制特定于每种方法的加工参数和含药物聚合物的组成来调节。如果目标是高药物含量，则在预制缝线上涂覆或接枝药物层允许保持缝线的拉伸强度要求。
Introduction: Drug-eluting sutures represent the next generation of surgical sutures since they fulfill their mechanical functions but also deliver the drug in their vicinity after implantation. These implants are produced by a variety of manufacturing processes. Drug-eluting sutures represent the next generation of surgical sutures since they fulfill their mechanical functions but also deliver the drug in their vicinity after implantation. These implants are produced by a variety of manufacturing processes. Two general approaches can be followed: (i) the ones that add the API into the material during the manufacturing process of the suture and (ii) the ones that load the API to an already manufactured suture.Areas covered: This review provides an overview of the current manufacturing processes for drug-eluting suture production and discusses their benefits and drawbacks depending on the type of drugs. The mechanical properties and the drug delivery profile of drug-eluting sutures are highlighted since these implants must fulfill both criteria.Expert opinion: For limited drug contents, melt extrusion and electrospinning are the emerging processes since the drug is added during the suture manufacture process. Advantageously, the drug release profile can be tuned by controlling the processing parameters specific to each process and the composition of the drug-containing polymer. If high drug content is targeted, the coating or grafting of a drug layer on a pre-manufactured suture allows for preservation of the tensile strength requirements of the suture.