Reply: Feasibility of Automated Partial-Volume Correction of SUVs in Current PET/CT Scanners: Can Manufacturers Provide Integrated, Ready-to-Use Software?
Reply: Feasibility of Automated Partial-Volume Correction of SUVs in Current PET/CT Scanners: Can Manufacturers Provide Integrated, Ready-to-Use Software?
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DOI：
10.2967/jnumed.108.051334
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发表时间：
2008-06
影响因子：
9.3
通讯作者：
I. Buvat;S. Bacharach;M. Soret
中科院分区：
文献类型：
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作者：
I. Buvat;S. Bacharach;M. Soret
对疾病活动进行评估。然而，成功实施这一程序需要一种可重复且相对简单的方法，可以在所有患者中进行。几种PVE校正方法，包括流行的恢复系数技术，需要在CT或MRI产生的解剖图像中测量病变尺寸。根据当前PET/CT扫描仪的尺寸估计，可以很容易地确定pve校正后的SUV。我们相信，随着CT或MRI横断面解剖成像技术的不断普及，再加上当前一代的PET扫描仪，可以通过自动算法实现这一目标，这些算法可以直接、轻松地提供pve校正后的SUV。直到最近，PVE校正的广泛使用主要受到这些混合扫描仪缺乏集成处理软件的阻碍。随着融合成像在临床实践中的广泛应用，这些局限性可能不会持续存在。我们相信制造商可以评估特定扫描仪的PVE校正恢复系数，并在安装到现场之前将其集成到扫描仪中。pve校正SUV的可用性将是在临床水平上常规使用该手术的有力一步，最终改善患者护理。我们推测，最终大多数扫描仪将集成自动PVE校正软件。从业者和行业都应该意识到这种演变的潜在优势，并采取积极措施实现它。与现有方案相比，集成PVE软件将增强SUV测量作为定量测量的作用和可靠性。除了对患者日常护理的影响外，这种校正方法有望增强PET在临床肿瘤学等相关学科领域的研究应用。随着PET/CT设备在世界各地的许多中心建立，准确的临床数据不仅需要来自先进的大型大学中心，也需要来自不同专业水平的社区的小型中心。集成算法的可用性可能会提高再现性并减少操作员相关的错误。采用与现有软件集成的自动校正程序将真正彻底改变这种强大模式在全球范围内的影响。应尽一切努力实现这一目标。
curate assessment of disease activity. However, successful implementation of this procedure would require a reproducible and relatively simple approach that can be performed on all patients. Several PVE correction methods, including the popular recovery coefficient technique, require measuring the lesion dimensions in anatomic images such those produced by CT or MRI. The size estimate from current PET/CT scanners provides the opportunity to determine the PVE-corrected SUV readily. We believe the everincreasing use of cross-sectional anatomic imaging with either CT or MRI along with the current-generation PET scanners can make this goal achievable through automated algorithms that provide the PVE-corrected SUV directly and easily. Until recently, the widespread use of PVE correction has been hampered primarily by the lack of integrated processing software with these hybrid scanners. With the use of fusion imaging in clinical practice becoming widespread, these limitations likely will not persist. We believe that manufacturers can assess the recovery coefficients for PVE correction for a particular scanner and integrate them into these scanners before they are installed at the site. The availability of a PVE-corrected SUV will be a strong step toward the routine use of this procedure at the clinical level, ultimately improving patient care. We speculate that eventually most scanners will have integrated automated PVE correction software. Both practitioners and the industry should be aware of the potential advantages of this evolution and take active steps toward bringing it about. Compared with the current schemes, integrated PVE software will strengthen the role and reliability of the SUV measurement as a quantitative measure. In addition to the impact on routine patient care, such correction methods are expected to enhance the research applications of PET in the field of clinical oncology and other related disciplines. With PET/CT facilities being established in many centers across the world, it would be desirable for accurate clinical data to be generated not only from advanced and large university centers but also from small centers in communities with varying levels of expertise. The availability of integrated algorithms would likely improve reproducibility and reduce operator-dependent errors. Adoption of automated correction procedures that have been integrated with existing software will truly revolutionize the impact of this powerful modality worldwide. Every effort should be made toward achieving this goal.