EFFECTS ON THE OFFSPRING OF CHRONIC LOW EXPOSURE CARBON-MONOXIDE DURING MICE PREGNANCY
EFFECTS ON THE OFFSPRING OF CHRONIC LOW EXPOSURE CARBON-MONOXIDE DURING MICE PREGNANCY
复制标题
DOI：
10.3109/15563657909010602
复制
发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
MOHRMANN, K
中科院分区：
文献类型：
--
作者：
ABBATIELLO, ER;MOHRMANN, K
研究了慢性低剂量一氧化碳对胎儿发育的影响。雌性瑞士韦氏小鼠从妊娠开始至足月每天吸入一氧化碳。记录每日体重，每4天测定一次血CO水平。记录每窝子代的数量。断奶时，每窝随机选取2只公鼠和2只母鼠进行迷宫跑研究。当小鼠6周大时，他们每天在迷宫中进行10次测试，直到学习发生。学习迷宫所需的天数和错误试验的次数被记录下来。虽然学习迷宫所需的天数没有显著增加，但实验组在此期间犯的错误数量却显著增加。学习迷宫需要更大的努力。
The effects of chronic low doses of CO on fetal development were studied. CO was administered daily by inhalation to female Swiss Webster mice from the beginning of gestation until term. Daily weights were recorded and CO blood levels determined every 4 days. The number of offspring in each litter was recorded. At weaning, 2 males and 2 females from each litter were randomly picked for maze running studies. When the mice were 6 wk old, they were tested daily, 10 trials/day, in the maze until learning had occurred. The number of days required to learn the maze and the number of incorrect trials were recorded. While there was no significant increase in the number of days needed to learn the maze, there was a significant increase in the number of errors made by the experimental group during this time. An increased effort was needed to learn the maze.