Biomimetic Semisynthesis of Arglabin from Parthenolide
Biomimetic Semisynthesis of Arglabin from Parthenolide
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小白菊内酯仿生半合成阿格拉宾
DOI：
10.1021/jo300888s
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发表时间：
2012-08-17
影响因子：
3.6
通讯作者：
Chen, Yue
中科院分区：
文献类型：
--
作者：
Zhai, Jia-Dai;Li, Dongmei;Chen, Yue
本研究以大量天然产物孤雌菊为原料，经三步反应半合成了临床应用的抗癌药物arglabin。该序列中的每一步都是高度立体选择性的，并且环氧化步骤中的底物依赖性立体选择性可以通过计算计算来解释。arglabin化学半合成的成功表明arglabin的生物合成可能以类似的途径进行。
The semisynthesis of arglabin, an anticancer drug in clinical application, is developed from abundant natural product parthenolide via three steps. Each step in this sequence is highly stereoselective, and the substrate-dependent stereoselectivity in the epoxidation step can be explained by computational calculations. The success of chemical semisynthesis of arglabin suggests that the biosynthesis of arglabin might proceed in a similar pathway.