Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation
Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation
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DOI：
10.1016/j.febslet.2007.06.073
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发表时间：
2007-08-07
期刊：
影响因子：
3.5
通讯作者：
Sobue, K.
中科院分区：
文献类型：
--
作者：
Yoshio, T.;Morita, T.;Sobue, K.
足状体和侵袭足状体是降解细胞外基质（ECM）并促进细胞侵袭的动态细胞粘附结构。我们最近报道，肌动蛋白结合蛋白caldesmon是一个关键的调节器的podosome形成。在这里，我们分析了钙调素参与足体/侵袭足介导的转化细胞和癌细胞的侵袭。钙调素的异位表达减少了足体/侵袭足的数量，降低了ECM降解活性，从而抑制了细胞侵袭。相反，钙调素的耗竭促进了足体/侵入足的形成和细胞侵袭。总之，我们的结果表明，钙调素作为一个有效的抑制癌细胞的侵袭。(c)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The podosome and invadopodium are dynamic cell-adhesion structures that degrade the extracellular matrix (ECM) and promote cell invasion. We recently reported that the actin-binding protein caldesmon is a pivotal regulator of podosome formation. Here, we analyzed the caldesmon's involvement in podosome/invadopodium-mediated invasion by transformed and cancer cells. The ectopic expression of caldesmon reduced the number of podosomes/invadopodia and decreased the ECM degradation activity, resulting in the suppression of cell invasion. Conversely, the depletion of caldesmon facilitated the formation of podosomes/invadopodia and cell invasion. Taken together, our results indicate that caldesmon acts as a potent repressor of cancer cell invasion. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.