Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides
Inactivation of myostatin by photo-oxygenation using catalyst-functionalized peptides
复制标题
使用催化剂功能化肽通过光氧作用灭活肌肉生长抑制素
DOI：
10.1039/c9cc04368c
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发表时间：
2019
影响因子：
4.9
通讯作者：
Hayashi Yoshio
中科院分区：
文献类型：
--
作者：
Okamoto Hideyuki;Taniguchi Atsuhiko;Usami Shoya;Taguchi Akihiro;Takayama Kentaro;Hayashi Yoshio
抑制肌肉生长抑制素是治疗肌营养不良症和其他肌萎缩性疾病的一种有吸引力的方法。通过配备开/关可切换光氧合催化剂来功能化肌生长抑制素结合肽。这种肽在近红外光下诱导肌肉生长抑制素的选择性氧化，导致肌肉生长抑制素失活。该肽显示出比原始肽高几个数量级的抑制效果。
Inhibition of myostatin is an attractive treatment for muscular dystrophy and other amyotrophic diseases. A myostatin-binding peptide was functionalized by equipped with an on/off switchable photo-oxygenation catalyst. This peptide induces a selective oxygenation of myostatin under near-infrared light, resulting in inactivation of myostatin. This peptide shows several orders of magnitude greater inhibitory effect than the original peptide.