Differences in response to sodium administration in normotensive white and black subjects.
Differences in response to sodium administration in normotensive white and black subjects.
复制标题
血压正常的白人和黑人受试者对钠给药的反应存在差异。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
M. Weinberger
中科院分区：
文献类型：
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作者：
F. Luft;C. Grim;J. T. Higgins;M. Weinberger
为了检查血压正常的黑人和白人受试者 PRA、PA 和肾电解质排泄可能存在的差异，我们研究了 68 名年龄匹配的受试者：19 名白人男性、19 名黑人男性、15 名白人女性和 15 名黑人女性。在输注2L生理盐水之前和之后测量PRA以评价肾素-醛固酮系统的抑制。监测钠、钾和肌酸酐随盐负荷的排泄 24 小时。盐负荷后的第二天早上，步行 2 小时后重复 PRA 和 PA 测量。然后限制膳食钠摄入并口服呋塞米（120 mg），以评估 PRA 和 PA 对钠和容量消耗的反应。白人和黑人受试者对生理盐水和呋塞米给药有相似的 PRA 和 PA 反应。在 24 小时内，黑人受试者在盐负荷后排出的钠和钾明显少于白人受试者。黑人受试者在盐负荷 24 小时后的 PRA 值也显着受到抑制。这些观察结果表明，黑人肾钠排泄可能存在种族差异，表现为尿钠排泄减少和盐负荷后 PRA 相对抑制。
In order to examine possible differences in PRA, PA, and renal electrolyte excretion in normotensive black and white subjects, we studied 68 age-matched subjects: 19 white men, 19 black men, 15 white women, and 15 black women. PRA was measured before and after the infusion of 2 L of normal saline to evaluate suppression of the renin-aldosterone system. The excretion of sodium, potassium, and creatinine in response to the salt load was monitored for 24 hr. PRA and PA measurements were repeated after 2 hr of ambulation on the morning following salt loading. Dietary sodium was then restricted and oral furosemide (120 mg) was administered in order to assess PRA and PA responsiveness to sodium and volume depletion. White and black subjects had similar PRA and PA responses to normal saline and furosemide administration. Over a 24 hr period, black subjects excreted significantly less sodium and potassium following the salt load than did white subjects. The PRA values of black subjects 24 hr following the salt load were significantly suppressed as well. These observations suggest that there may be racial differences in renal sodium excretion reflected by decreased urinary sodium excretion and a relative suppression of PRA following a salt load in black persons.