Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study
Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study
复制标题
DOI：
10.1007/s00535-011-0378-x
复制
发表时间：
2011-06-01
影响因子：
6.3
通讯作者：
Sata, Michio
中科院分区：
文献类型：
--
作者：
Kawaguchi, Takumi;Shiba, Naoto;Sata, Michio
背景：缺乏运动是非酒精性脂肪性肝病（NAFLD）发展的危险因素。“混合训练”是一种同时涉及随意肌肉收缩和电性肌肉收缩的训练，即使在短时间的运动后，也会对肌肉产生有益的改变。本研究的目的是探讨混合训练对NAFLD患者的治疗效果。方法将35例对生活方式咨询有抵抗的NAFLD患者分为混合训练组（n = 12）和对照组（n = 23）。在混合训练组，股四头肌和腘绳肌每周两次，每次19分钟。在对照组，患者接受生活方式咨询。干预12周后评估混合训练的治疗效果。结果与对照组相比，混合训练组血清丙氨酸转氨酶（ALT）水平和肝脂肪变性等级显著降低（-14.1 +/- A 5.8 vs. 3.5 +/- A 5.4 IU/mL, P < 0.05, -0.67 +/- A 0.19 vs. 0.09 +/- A 0.06, P < 0.01）。两组骨骼肌质量没有明显变化。混合训练组胰岛素抵抗稳态模型评估（HOMA-IR）值和血清IL-6水平的下降明显大于对照组（-6.2 +/- A 3.2 vs. 0.4 +/- A 0.6; P < 0.05, -3.1 +/- A 1.1 vs. 1.1 +/- A 0.5 pg/mL; P < 0.01）。结论随意肌和电性肌收缩混合训练可改善NAFLD患者肝脂肪变性，降低胰岛素抵抗和血清IL-6水平。
Background Physical inactivity is a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). "Hybrid training", a training that involves both voluntary and electrical muscle contractions, causes beneficial alterations in muscles even after short durations of exercise. The aim of this study was to investigate the therapeutic efficacy of hybrid training in patients with NAFLD.Methods Thirty-five patients with NAFLD who were resistant to lifestyle counseling were assigned to a hybrid-training group (n = 12) or a control group (n = 23). In the hybrid-training group, quadriceps and hamstrings were contracted voluntarily or electrically for 19 min twice a week. In the control group, patients received lifestyle counseling. The therapeutic efficacy of the hybrid training was evaluated after 12 weeks of the intervention.Results Serum alanine aminotransferase (ALT) levels and hepatic steatosis grade were significantly decreased in the hybrid-training group compared to that of the control group (-14.1 +/- A 5.8 vs. 3.5 +/- A 5.4 IU/mL; P < 0.05, -0.67 +/- A 0.19 vs. 0.09 +/- A 0.06 grade; P < 0.01, respectively). No significant changes were seen between the two groups in skeletal muscle mass. The decreases in homeostasis model assessment of insulin resistance (HOMA-IR) value and in serum IL-6 levels were significantly greater in the hybrid-training group than in the control group (-6.2 +/- A 3.2 vs. 0.4 +/- A 0.6; P < 0.05, -3.1 +/- A 1.1 vs. 1.1 +/- A 0.5 pg/mL; P < 0.01, respectively).Conclusion Hybrid training of voluntary and electrical muscle contractions improved hepatic steatosis and reduced insulin resistance and serum IL-6 levels in NAFLD patients who are resistant to lifestyle counseling.