ABNORMAL LIPOPROTEIN PHOSPHOLIPID-COMPOSITION IN PATIENTS WITH ESSENTIAL-HYPERTENSION
ABNORMAL LIPOPROTEIN PHOSPHOLIPID-COMPOSITION IN PATIENTS WITH ESSENTIAL-HYPERTENSION
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DOI：
10.1016/0021-9150(95)05573-f
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发表时间：
1995-10-01
期刊：
影响因子：
5.3
通讯作者：
LITHELL, H
中科院分区：
文献类型：
--
作者：
BAGDADE, JD;BUCHANAN, WF;LITHELL, H
原发性高血压（EH）患者和遗传性高血压动物的血管细胞膜中游离胆固醇和带负电荷的磷脂的含量发生了改变，这可能改变了它们的功能。由于膜和脂蛋白脂质自由交换，脂蛋白的脂质组成可能是血管和其他细胞含量的间接测量。为了确定是否存在异常的高血压患者的脂蛋白的脂质和磷脂组成，30 EH（11名女性，19名男性）和20名血压正常的对照组进行了研究。由于脂蛋白组成的许多参数存在显著的性别差异，因此分别检查了雄性和雌性数据。高血压组男女血浆TG、VLDL + LDL和HDL（2）脂质水平均高于各自对照组。不仅钙结合磷脂磷脂酰肌醇（PI）+磷脂酰丝氨酸（PS）和膜流化剂磷脂酰乙醇胺（PE）在其VLDL + LDL中显著减少，而且所有磷脂（L，鞘磷脂（SPH），PI + PS和PE）相对于其HDL（2）和HDL（3）亚组分中的中性脂质含量均显著减少。EH女性中脂蛋白FC和磷脂的这些方向性变化显著增加了血浆中EH FC/PC（mol/mol）比值，这是一种新的心血管危险因素，（EH 1.08 ± 0.22 vs.对照0.86 ± 0.08; P < 0.01），并降低男女EH患者HDL（2）和HDL（3）的SPH/PC比值，这些结果表明，脂蛋白在正常血脂的高血压妇女相对丰富的FC和高血压患者的男性和女性在某些磷脂耗尽。如果EH患者血管组织膜缺乏与脂蛋白相同的带负电荷的磷脂，则其功能特性可能改变，血管张力增加。
Vascular cell membranes from patients with essential hypertension (EH) and animals with genetic forms of hypertension have been found to have alterations in the content of free cholesterol and negatively charged phospholipids that may modify their function, Since membrane and lipoprotein lipids exchange freely the lipid composition of lipoproteins may be an indirect measure of the content of vascular and other cells. To determine whether abnormalities are present in the lipid and phospholipid composition of lipoproteins from patients with EH, 30 EH (11 women; 19 men) and 20 normotensive control subjects were studied. Since significant gender differences were present in a number of parameters of lipoprotein composition, male and female data were examined separately. The EH group of both sexes tended to have higher plasma TG and VLDL + LDL and HDL(2) lipid levels than their respective controls. Not only were the calcium-binding phospholipids phosphatidylinositol (PI) + phosphatidylserine (PS), and the membrane fluidizer phosphatidylethanolamine (PE) significantly reduced in their VLDL + LDL, but all phospholipids (L, sphingomyelin (SPH), PI + PS, and PE) were significantly reduced relative to their neutral lipid content in both the HDL(2) and HDL(3) subfractions. These directional changes in lipoprotein FC and phospholipid in the EH women significantly increased the EH FC/PC (mol/mol) ratio in their plasma, a new cardiovascular risk factor, (EH 1.08 +/- 0.22 vs. control 0.86 +/- 0.08; P < 0.01) and lowered the SPH/PC ratio of HDL(2) and HDL(3) in EH patients of both sexes, These findings show that lipoproteins in normolipidemic EH women are relatively enriched in FC and in EH patients of both sexes depleted in certain phospholipids. If membranes of vascular tissues in EH are deficient in the same negatively charged phospholipids lacking in lipoproteins, their functional properties could be altered and vascular tone increased.