Temporolimbic volume reductions in schizophrenia
Temporolimbic volume reductions in schizophrenia
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DOI：
10.1001/archpsyc.57.8.769
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发表时间：
2000-08-01
影响因子：
--
通讯作者：
Gur, RC
中科院分区：
文献类型：
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作者：
Gur, RE;Turetsky, BI;Gur, RC
背景：精神分裂症的神经解剖学研究报告了颞边缘异常。大多数磁共振成像研究都评估了主要患有慢性精神分裂症的男性的小样本。我们的目标是通过可靠的分割方法评估分段颞叶亚区域的性别差异，将体积与临床和神经认知参数联系起来。方法：对 100 名精神分裂症患者（58 名男性，42 名女性；39 名未接受过抗精神病药治疗，61 名既往接受过治疗）和 110 名健康对照者（51 名男性，59 名女性）进行了磁共振成像。检查颞边缘（海马和杏仁核）和新皮质区域（颞上回和颞极）的灰质和白质体积。同时评估症状、功能和神经认知。结果：男性（7%）和女性（8.5%）精神分裂症患者的海马灰质体积减少。然而，在杏仁核中，男性（8%）的杏仁核体积明显减少，而女性（10.5%）的杏仁核体积则增加。颞极磁共振成像显示男性（10%）和女性（8.5%）的灰质减少。对于颞上回，下降幅度仅在男性中超过全脑（11.5%）。海马体积在很大程度上与临床测量不相关，但对于所有组来说，较高的海马体积与更好的记忆表现相关。健康女性的皮质体积与更好的记忆表现相关。结论：精神分裂症与颞边缘结构灰质体积减少有关。男性的所有区域均出现减少，而女性的海马体积减少，但杏仁核体积增加。这些异常在首发精神分裂症患者中很明显，并且与认知表现的相关性比与症状严重程度的相关性更强。
Background: Neuroanatomic studies of schizophrenia have reported temporolimbic abnormalities. Most magnetic resonance imaging studies have evaluated small samples of primarily men with chronic schizophrenia. Our goal was to evaluate sex differences in segmented temporal lobe subregions with reliable parcellation methods, relating volume with clinical and neurocognitive parameters.Methods: Magnetic resonance imaging was performed in 100 patients with schizophrenia (58 men, 42 women; 39 neuroleptic naive, 61 previously treated) and 110 healthy controls (51 men, 59 women). Gray and white matter volumes of temporolimbic (hippocampus and amygdala) and neocortical regions (superior temporal gyrus and temporal pole) were examined. Symptoms, functioning, and neurocognition were assessed concurrently.Results: Hippocampal gray matter volume was reduced in men (7%) and women (8.5%) with schizophrenia. In the amygdala, however, decreased volume was evident for men (8%) whereas women (10.5%) had increased volume. Magnetic resonance imaging of the temporal pole showed decreased gray matter in men (10%) and women (8.5%). For the superior temporal gyrus, the decrease exceeded that of whole-brain only in men (11.5%). Volumes were largely uncorrelated with clinical measures, but higher hippocampal volumes were associated with better memory performance for all groups. Cortical volumes were associated with better memory performance in healthy women.Conclusion: Schizophrenia is associated with reduced gray matter volume in temporolimbic structures. In men, reduction was manifested in all regions, whereas women showed decreased hippocampal volumes but increased amygdala volumes. The abnormalities are evident in patients with first-episode schizophrenia and correlate more strongly with cognitive performance than with symptom severity.