Molecular structure and biological and pharmacological properties of 3-hydroxy-2-methyl-1-(beta-D-ribofuranosyl or pyranosyl)-4-pyridinone: potential iron overload drugs for oral administration.
Molecular structure and biological and pharmacological properties of 3-hydroxy-2-methyl-1-(beta-D-ribofuranosyl or pyranosyl)-4-pyridinone: potential iron overload drugs for oral administration.
复制标题
3-羟基-2-甲基-1-(β-D-呋喃核糖基或吡喃糖基)-4-吡啶酮的分子结构和生物和药理学特性：潜在的口服铁超载药物。
DOI：
10.1016/s0960-894x(98)00569-1
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Arif,AM
中科院分区：
文献类型：
--
作者：
Liu,G;Bruenger,FW;Miller,SC;Arif,AM
Replacing alkyl groups by sugar moieties at N-1 position of 3-hydroxyl-2-methyl-4-pyridinone did not affect the geometry of the iron chelating sites but increased the hydrophilic nature. The formation of a polymer cluster through the intermolecular hydrogen bonds was also revealed by X-ray crystal structure analysis for the first time in all known 3-hydroxy-4-pyridinone crystal structures. Iron removal from ferritin by the title compounds was more efficient than with DFO.
