Emergence of airway smooth muscle functions related to structural malleability.
Emergence of airway smooth muscle functions related to structural malleability.
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DOI：
10.1152/japplphysiol.01192.2010
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发表时间：
2011-04
影响因子：
3.3
通讯作者：
C. Seow;J. Fredberg
中科院分区：
文献类型：
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作者：
C. Seow;J. Fredberg
平滑肌细胞等复杂系统的功能是分子和分子聚集体之间主动相互作用的结果。这些分子相互作用的新兴宏观表现，例如长度-力关系及其相关的长度适应，已得到充分记录，但引起这些新兴肌肉行为的分子成分和组织仍然很大程度上未知。在这篇小综述中，我们描述了气道平滑肌的新兴特性，这些特性似乎源于细胞结构固有的脆弱性，这已越来越被认为是一种独特且重要的平滑肌属性。我们还描述了分子相互作用（基于直接和间接证据），这些相互作用可能赋予脆弱的结构元件可塑性，从而使肌肉能够适应细胞尺寸的大而频繁的变化。了解平滑肌的工作原理可能取决于我们如何将分子事件与其新兴的宏观功能联系起来。
The function of a complex system such as a smooth muscle cell is the result of the active interaction among molecules and molecular aggregates. Emergent macroscopic manifestations of these molecular interactions, such as the length-force relationship and its associated length adaptation, are well documented, but the molecular constituents and organization that give rise to these emergent muscle behaviors remain largely unknown. In this minireview, we describe emergent properties of airway smooth muscle that seem to have originated from inherent fragility of the cellular structures, which has been increasingly recognized as a unique and important smooth muscle attribute. We also describe molecular interactions (based on direct and indirect evidence) that may confer malleability on fragile structural elements that in turn may allow the muscle to adapt to large and frequent changes in cell dimensions. Understanding how smooth muscle works may hinge on how well we can relate molecular events to its emergent macroscopic functions.