Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients
Association of serum uric acid levels with the progression of Parkinson's disease in Chinese patients
复制标题
中国患者血清尿酸水平与帕金森病进展的关系
DOI：
10.3760/cma.j.issn.0366-6999.2012.04.005
复制
发表时间：
2012-02-20
影响因子：
6.1
通讯作者：
Xu Ping-yi
中科院分区：
文献类型：
--
作者：
Sun Cong-cong;Luo Fei-fei;Xu Ping-yi
背景尿酸（UA）被怀疑在帕金森病（PD）中发挥神经保护作用。方法采用尿酸比色法测定411例PD患者和396例正常对照者的血清UA水平，同时测定血清肌酐（Scr）水平，以减少因肾排泄功能差异而引起的偏倚。采用Hoehn-Yahr（H&Y）评分法和病程评分，PD组根据H&Y评分法分为3个亚组。采用独立样本t检验分析PD组与对照组之间的差异。进行协方差的多重分析以分析PD亚组之间的差异。采用斯皮尔曼等级相关法评价血清UA或Scr水平与疾病进展的关系。结果PD患者血清UA水平明显低于对照组（（243.38 ± 78.91）vs.（282.97 ± 90.80）μ mol/L，P
Background Uric acid (UA) is suspected to play a neuro-protective role in Parkinson's disease (PD). This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a relatively large population of Chinese patients.Methods Serum UA levels were measured from 411 Chinese PD patients and 396 age-matched controls; following the uric acid colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function. The disease progression was scored by Hoehn and Yahr (H&Y) scales and disease durations; PD group was divided into 3 subgroups according to H&Y scales. Independent-samples t test was performed to analyze the differences between PD group and control group. Multiple analysis of covariance was performed to analyze the differences between PD subgroups. Spearman rank-correlation was performed to evaluate the associations between serum UA or Scr level and disease progression.Results PD patients were found to have significantly lower levels of serum UA than controls ((243.38 +/- 78.91) vs. (282.97 +/- 90.80) mu mol/L, P