Ocular measurements throughout the adult life span of rhesus monkeys
Ocular measurements throughout the adult life span of rhesus monkeys
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DOI：
10.1167/iovs.02-0944
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发表时间：
2003-06-01
影响因子：
4.4
通讯作者：
Herndon, JG
中科院分区：
文献类型：
--
作者：
Fernandes, A;Bradley, DV;Herndon, JG
目的.研究恒河猴（Macaca mulatta）成年期眼成分与屈光的关系。对111只5 ~ 31岁的猴子进行了一项横断面研究，包括散瞳视网膜检影、A型超声检查、裂隙灯检查、间接检眼镜检查和角膜曲率测量。根据超声心动图测量透镜厚度、前房和玻璃体腔深度。分析了这些变量的相关性，以及它们与年龄和性别的关系。在5至15岁的猴中，平均屈光值为+1.5 D，SD为1.7 D，保持在先前确定的发育渐近线+2 D附近。在15岁以上的猴子中，个体间差异更大（SD = 4.5 D），包括极度近视和远视。角膜随着年龄的增长而变得更陡。眼轴长度增加到12岁，20岁后开始缩短。构成眼长的其他单个组成部分也发生了变化。这些与年龄相关的变化包括玻璃体腔深度减少、前房深度减少和透镜厚度增加。一般来说，男性的眼睛比女性长。老年猴的眼睛更容易表现出白内障和玻璃疣，但与年龄相关的视网膜色素上皮局灶性萎缩的变化没有达到统计学意义。结论.猴子眼睛的组成部分随着年龄的变化，其变化模式与人类相似。可能对屈光不利的个体眼部组件的屈光不正相关变化似乎可以通过其他组件的变化进行补偿。（Invest Ophtbalmol维斯科学。2003;44：2373-2380）DOI：10.1167/iovs.02-0944。
Purpose. To examine the relationship of ocular components to refraction throughout the adult life span of the rhesus monkey (Macaca mulatta).Methods. Cycloplegic retinoscopy, A-scan ultrasonography, slit lamp examination, indirect ophthalmoscopy, and keratometry were performed in a cross-sectional study of 111 monkeys, aged 5 to 31 years. Lens thickness and anterior and vitreous chamber depths were measured from the echograms. The intercorrelations; of these variables were analyzed, as well as their association with age and sex.Results. In monkeys aged 5 to 15 years, the mean refractive value of + 1.5 D with an SD of 1.7 D was maintained near the previously established developmental asymptote of +2 D. In monkeys older than 15 years, there was greater interindividual variation (SD = 4.5 D), including extreme myopia and hyperopia. The cornea became steeper with age. The axial length of the eyes increased up to 12 years of age and began to shorten after 20 years. Changes also occurred in the other individual components that constitute eye length. These age-related changes were decreased vitreous chamber depth, decreased anterior chamber depth, and increased lens thickness. In general, males had longer eyes than females. The eyes of old monkeys were more likely to exhibit cataract and drusen, but age-related changes in focal atrophy of the retinal pigment epithelium did not achieve statistical significance. Conclusions. The components of the monkey eye change with age in a pattern similar to that reported in humans. Age-related changes in individual ocular components that could be detrimental to refraction appear to be compensated for by changes in other components. (Invest Ophtbalmol Vis Sci. 2003;44: 2373-2380) DOI: 10.1167/iovs.02-0944.