Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells
Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells
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DOI：
10.1016/s0896-6273(00)81197-6
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发表时间：
2000-06-01
期刊：
影响因子：
16.2
通讯作者：
Fakler, B
中科院分区：
文献类型：
--
作者：
Oliver, D;Klöcker, N;Fakler, B
中枢神经系统中的快速抑制性突触传递由亲离子型GABA或甘氨酸受体介导。听觉外毛细胞存在一种独特的抑制性突触，该突触使用Ca2+可渗透的兴奋性乙酰胆碱受体来激活由小电导钙激活钾（SK）通道介导的超极化钾电流。它示出在这个突触的单一抑制性突触后电流介导的SK 2通道，并迅速发生，与上升和衰减时间常数类似的6毫秒和类似的30毫秒，分别。该时间过程由SK通道的Ca 2+门控而不是细胞内Ca 2+的变化决定。结果表明，快速耦合之间的兴奋性离子型神经递质受体和抑制性离子通道，并意味着快速，局部的变化，突触下的钙离子水平。
Fast inhibitory synaptic transmission in the central nervous system is mediated by ionotropic GABA or glycine receptors. Auditory outer hair cells present a unique inhibitory synapse that uses a Ca2+-permeable excitatory acetylcholine receptor to activate a hyperpolarizing potassium current mediated by small conductance calcium-activated potassium (SK) channels. It is shown here that unitary inhibitory postsynaptic currents at this synapse are mediated by SK2 channels and occur rapidly, with rise and decay time constants of similar to 6 ms and similar to 30 ms, respectively. This time course is determined by the Ca2+ gating of SK channels rather than by the changes in intracellular Ca2+. The results demonstrate fast coupling between an excitatory ionotropic neurotransmitter receptor and an inhibitory ion channel and imply rapid, localized changes in subsynaptic calcium levels.