Successful rescue of severe hypernatraemia (196 mmol/L) by treatment with hypotonic fluid
Successful rescue of severe hypernatraemia (196 mmol/L) by treatment with hypotonic fluid
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DOI：
10.1258/000456307781646120
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发表时间：
2007-09-01
影响因子：
2.2
通讯作者：
McGonigle, Richard J. S.
中科院分区：
文献类型：
--
作者：
Jeffery, Jinny;Ayling, Ruth M.;McGonigle, Richard J. S.
高钠血症超过160 mmol/L被认为是重度。该病例报告了一例发生极端高钠血症的患者，血清钠浓度为196 mmol/L。已知患者患有慢性肾损害，因继发于脱水的肾功能急性恶化而入院。这被认为是继发于口服液体摄入不足（与抑郁症相关）和锂诱导的肾源性尿崩症伴失盐性肾病。患者尿钠排泄量高，但也处于纯水丢失状态，如尿液渗透压相对于血浆渗透压不适当低所证明，并成功接受低渗静脉输液和去氨加压素治疗。
Hypernatraemia over 160 mmol/L is considered to be severe. This case reports a patient who developed extreme hypernatraemia with a serum sodium concentration of 196 mmol/L. The patient was known to have chronic renal impairment and was admitted with acute deterioration of renal function secondary to dehydration. This was considered to be secondary to poor oral fluid intake (related to depression) and lithium-induced nephrogenic diabetes insipiclus with salt-losing nephropathy. The patient had a high urinary sodium excretion but was also in a pure water losing state as evidenced by an inappropriately low urine osmolality for the plasma osmolality and was successfully treated with hypotonic intravenous fluid and desmopressin.