Metformin Alters the Chemotaxis and Flagellar Motility of Escherichia coli.
Metformin Alters the Chemotaxis and Flagellar Motility of Escherichia coli.
复制标题
二甲双胍改变大肠杆菌的趋化性和鞭毛运动
DOI：
10.3389/fmicb.2021.792406
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发表时间：
2021
影响因子：
5.2
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Ye Y;Jiang P;Huang C;Li J;Chen J;Wang L;Lin Y;Wang F;Liu J
二甲双胍是一种双胍分子，被广泛用于治疗2型糖尿病和代谢综合征。虽然已知二甲双胍通过改变肠道微生物代谢来延长寿命，但二甲双胍如何影响和改变微生物的生理行为仍不清楚。在此，我们研究了二甲双胍对模式生物大肠杆菌（E。大肠杆菌），包括在细菌生命中起重要作用的趋化性和鞭毛运动性的变化。二甲双胍对大肠杆菌有驱避作用。大肠杆菌中表达。此外，我们还研究了E.结果表明，二甲双胍能延长大肠杆菌对葡萄糖和α-甲基-DL-天冬氨酸（MeAsp）两种典型引诱剂的趋化恢复时间，并随刺激物浓度的增加而延长。对E.包括鞭毛运动和细胞游动。这种抑制是由于鞭毛马达产生的扭矩减少。我们发现二甲双胍改变了大肠杆菌的趋化性和鞭毛运动性。大肠杆菌中的表达可能为二甲双胍对其他微生物的影响提供潜在的启示。
Metformin is a biguanide molecule that is widely prescribed to treat type 2 diabetes and metabolic syndrome. Although it is known that metformin promotes the lifespan by altering intestinal microorganism metabolism, how metformin influences and alters the physiological behavior of microorganisms remains unclear. Here we studied the effect of metformin on the behavior alterations of the model organism Escherichia coli (E. coli), including changes in chemotaxis and flagellar motility that plays an important role in bacterial life. It was found that metformin was sensed as a repellent to E. coli by tsr chemoreceptors. Moreover, we investigated the chemotactic response of E. coli cultured with metformin to two typical attractants, glucose and α-methyl-DL-aspartate (MeAsp), finding that metformin prolonged the chemotactic recovery time to the attractants, followed by the recovery time increasing with the concentration of stimulus. Metformin also inhibited the flagellar motility of E. coli including the flagellar motor rotation and cell swimming. The inhibition was due to the reduction of torque generated by the flagellar motor. Our discovery that metformin alters the behavior of chemotaxis and flagellar motility of E. coli could provide potential implications for the effect of metformin on other microorganisms.
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影响因子：
64.8
作者：
Alon, U;Surette, MG;Leibler, S
通讯作者：
Leibler, S
影响因子：
3.4
作者：
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影响因子：
3.2
作者：
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影响因子：
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作者：
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影响因子：
64.8
作者：
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