Shear Wave Elastography and Quantitative Ultrasound as Biomarkers to Characterize Deep Vein Thrombosis In Vivo
Shear Wave Elastography and Quantitative Ultrasound as Biomarkers to Characterize Deep Vein Thrombosis In Vivo
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DOI：
10.1002/jum.15863
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发表时间：
2021-10-29
影响因子：
2.3
通讯作者：
Cloutier，Guy
中科院分区：
文献类型：
--
作者：
Bosio，Guillaume;Zenati，Nora;Cloutier，Guy
目的探讨下肢深静脉血栓形成（DVT）住院患者的剪切波弹性成像（SWE）和定量超声（QUS）参数。计算SWE和QUS特征，以区分肝素或口服抗凝剂治疗后第0天、第7天和第30天的血栓。计算来自SWE的杨氏模量，以及反映血凝块结构的QUS零差K分布（HKD）参数。在凝块的近端区域，相干-弥散背散射中位数的HKD比从第7天到第30天显著降低（P= 0.036），而弥散-总背散射中位数的HKD比从第7天到第30天显著增加（P= 0.0491）。在凝块的远端区，回声包络中值的HKD标准化强度显示从第0天到第30天显著增加（P= .0062）。随着时间的推移，没有SWE特征显示出统计学显著差异。尽管如此，低中位数的杨氏模量凝块内的患者谁开发了肺栓塞的趋势observed.ConclusionQUS功能可能是相关的，以表征凝块的演变随着时间的推移。在更大的数据集上对其临床解释和验证的进一步分析值得研究。
ObjectiveInvestigate shear wave elastography (SWE) and quantitative ultrasound (QUS) parameters in patients hospitalized for lower limb deep vein thrombosis (DVT).MethodSixteen patients with DVT were recruited and underwent SWE and radiofrequency data acquisitions for QUS on day 0, day 7, and day 30 after the beginning of symptoms, in both proximal and distal zones of the clot identified on B‐mode scan. SWE and QUS features were computed to differentiate between thrombi at day 0, day 7, and day 30 following treatment with heparin or oral anticoagulant. The Young's modulus from SWE was computed, as well as QUS homodyned K‐distribution (HKD) parameters reflecting blood clot structure. Median and interquartile range of SWE and QUS parameters within clot were taken as features.ResultsIn the proximal zone of the clot, the HKD ratio of coherent‐to‐diffuse backscatter median showed a significant decrease from day 7 to day 30 (P= .036), while the HKD ratio of diffuse‐to‐total backscatter median presented a significant increase from day 7 to day 30 (P= .0491). In the distal zone of the clot, the HKD normalized intensity of the echo envelope median showed a significant increase from day 0 to day 30 (P= .0062). No SWE features showed statistically significant differences over time. Nonetheless, a trend of lower median of Young's modulus within clot for patients who developed a pulmonary embolism was observed.ConclusionQUS features may be relevant to characterize clot's evolution over time. Further analysis of their clinical interpretation and validation on a larger dataset would deserve to be studied.