TRP Channels

TRP Channels
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DOI:
10.1002/cphy.c110026
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发表时间:
2012-01-01
影响因子:
5.8
通讯作者:
Voets, Thomas
Voets, Thomas
中科院分区:
医学1区
文献类型:
--
作者:
Gees, Maarten;Owsianik, Grzegorz;Voets, Thomas

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TRP通道构成了一个阳离子通道形成蛋白的大超家族,它们都与果蝇瞬时受体电位(TRP)位点的基因产物有关。在哺乳动物中,已经鉴定出28种不同的TRP通道基因,它们表现出多种功能特性,并发挥不同的细胞和生理作用。在本文中,我们对哺乳动物TRP通道的表达、功能和(病理)生理作用进行了简要系统的总结。(C) 2012年美国生理学会。物理学报,2012(2):563-608。
TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels. (C) 2012 American Physiological Society. Compr Physiol 2: 563-608, 2012.