Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxylapatite. A beagle dog study
Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxylapatite. A beagle dog study
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DOI：
10.1016/j.jpor.2010.10.001
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Akagawa, Yasumasa
中科院分区：
文献类型：
--
作者：
Kubo, Takayasu;Doi, Kazuya;Akagawa, Yasumasa
目的：在 3 只比格犬的下颌骨中评估两种不同形状的互连多孔羟基磷灰石钙 (IP-CHA) 颗粒刺激的骨再生。方法：使用不同形状的 IP-CHA，球形（球形 IP-CHA 颗粒）和不规则形状（不规则形状 IP-CHA 颗粒）。在每只动物的右下颌骨中制备两个骨槽（直径3毫米，深度5毫米），其中右前磨牙已被拔除，并且愈合时间为3个月。将两种类型的 IP-CHA 填充到牙槽中以刺激骨再生。在填充后第4、8和12周对新骨形成进行组织学评估。结果：第4周时，任何骨槽中几乎没有明显的骨形成。 8周时，在颗粒之间检测到新形成的骨，但在孔中未检测到。相比之下，在第12周时，不仅在颗粒之间而且在颗粒孔内部都清楚地观察到骨形成。比较第 8 周和第 12 周时的两个部位，在接受不规则形状 IP-CHA 的部位检测到更多的骨形成，而不是接受球形 IP-CHA 的部位。结论：这些结果表明，使用不规则形状 IP-CHA 可以增强骨再生。这项初步研究的结果表明，不规则形状的 IP-CHA 颗粒作为骨再生支架可能比球形颗粒更有用。 (C) 2010 年日本修复学会。由爱尔兰爱思唯尔出版。版权所有。
Purpose: Bone regeneration stimulated by two different shapes of interconnected porous calcium hydroxyapatite (IP-CHA) granules was evaluated in the mandibles of 3 beagle dogs.Methods: Deferent shapes of IP-CHA were used, spherical (spherical shaped IP-CHA granules) and irregular shapes (irregularly shaped IP-CHA granules). Two bone sockets (3 mm in diameter and 5 mm in depth) were prepared in the right edentulous mandible of each animal where right premolars had been extracted and sites healed for 3 months. The two types of IP-CHA were filled into the sockets to stimulate bone regeneration. New bone formation was evaluated histologically at 4, 8 and 12 weeks after filling.Results: At 4 weeks, little bone formation was apparent in any of the bony sockets. At 8 weeks, newly formed bone was detected between the granules but not in the pores. In contrast, at 12 weeks, bone formation was clearly observed not only between the granules but also inside the granule pores. Comparing the two sites at 8 and 12 weeks, more bone formation was detected in sites receiving irregularly shaped IP-CHA than in sites receiving spherical IP-CHA.Conclusion: These results indicate that use of irregularly shaped IP-CHA may enhance bone regeneration. The results of this preliminary study suggest that irregularly shaped IP-CHA granules may have more possible usefulness than spherically shaped granules as a scaffold for bone regeneration. (C) 2010 Japan Prosthodontic Society. Published by Elsevier Ireland. All rights reserved.