Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization.
Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization.
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DOI：
10.1016/j.biopsych.2008.12.020
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发表时间：
2009-05-15
影响因子：
10.6
通讯作者：
Vezina, Paul
中科院分区：
文献类型：
--
作者：
Singer, Bryan F.;Tanabe, Lauren M.;Gorny, Grazyna;Jake-Matthews, Charmaine;Li, Yilin;Kolb, Bryan;Vezina, Paul
Systemic exposure to amphetamine (AMPH) leads to a number of long-lasting neuroadaptations including changes in dendritic morphology in rat forebrain. It remains unknown whether these changes relate to associative drug conditioning or to non-associative drug sensitization, two forms of plasticity produced by systemic exposure to AMPH. We compared the behavioral, neuronal and morphological consequences of exposing rats to intraperitoneal (IP) AMPH to those of exposure to AMPH applied to the ventral tegmental area (VTA), infusions that sensitize AMPH-induced locomotion and nucleus accumbens (NAcc) DA overflow but do not produce drug conditioning. Both IP and VTA AMPH exposure sensitized locomotion and NAcc DA overflow but only IP AMPH exposure produced conditioned locomotion. Importantly, while IP AMPH exposure increased spine density, dendritic length and branching in the NAcc, exposure to VTA AMPH produced the opposite effects. A similar differentiation of effects was observed in cortical areas. Together these findings suggest that the morphological changes seen following IP AMPH exposure reflect associative drug conditioning rather than non-associative drug sensitization. The decreases observed in the NAcc of VTA AMPH exposed rats may reflect the inability of these infusions to support conditioning.
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影响因子：
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通讯作者：
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影响因子：
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