Role of high density lipoproteins in the regression of atherosclerosis.
Role of high density lipoproteins in the regression of atherosclerosis.
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DOI：
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发表时间：
1992-12
期刊：
影响因子：
37.8
通讯作者：
J. Badimón;V. Fuster;L. Badimón
中科院分区：
文献类型：
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作者：
J. Badimón;V. Fuster;L. Badimón
动脉粥样硬化是一种缓慢进展的疾病，其特征是胆固醇在血管壁内积聚。血浆脂蛋白是在血液中转运脂质的复杂脂质和蛋白质组合物的颗粒。低密度脂蛋白（LDL）和高密度脂蛋白（HDL）是主要的胆固醇载体脂蛋白。LDL似乎负责将脂质（胆固醇）从肝脏输送到组织。令人信服的证据支持这一概念，即沉积在动脉病变的脂质主要来自血浆LDL。术语“胆固醇逆向转运”描述了胆固醇从肝外组织转运到肝脏，在那里它可以被代谢。胆固醇逆向转运是清除肝外组织中可交换胆固醇的主要途径。据推测，血浆HDL颗粒的主要作用是作为组织胆固醇的清除剂。高水平的血浆HDL可预防冠状动脉疾病（CAD）的假设最初由巴尔等人在20世纪50年代早期提出，但直到1977年Tromso和Fragrant研究证实之前一直被忽视，该研究显示HDL血浆水平与CAD发病率之间呈反比关系。在包括8个国家在内的15项主要实验研究中也得到了类似的观察结果。（250字处删节）
Atherosclerosis is a slowly progressive disease characterized by the accumulation of cholesterol within the vessel wall. Plasma lipoproteins are particles of complex lipid and protein composition that transport lipids in blood. Low density lipoproteins (LDL) and high density lipoproteins (HDL) are the major cholesterol-carrier lipoproteins. LDL seem to be responsible for the delivery of lipids (cholesterol) from the liver to the tissues. Compelling evidence supports the concept that the lipids deposited in the arteriosclerotic lesions are derived primarily from plasma LDL. The term "reverse cholesterol transport" describes the transport of cholesterol from extrahepatic tissues to the liver, where it may be metabolized. Reverse cholesterol transport seems to be the major route for removal of the exchangeable cholesterol deposited in the extrahepatic tissue. It has been postulated that a major role of the plasma HDL particle is to act as a scavenger of tissue cholesterol. The hypothesis that high levels of plasma HDL are protective against coronary artery disease (CAD) was initially proposed by Barr et al in the early 1950s, but it was overlooked until confirmed by the Tromso and Framingham studies in 1977, which showed an inverse relation between HDL plasma levels and incidence of CAD. Similar observations have been made in 15 major experimental studies including eight countries.(ABSTRACT TRUNCATED AT 250 WORDS)