Glucocorticoids and insulin both modulate caloric intake through actions on the brain
Glucocorticoids and insulin both modulate caloric intake through actions on the brain
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DOI：
10.1113/jphysiol.2007.136051
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发表时间：
2007-09-01
影响因子：
5.5
通讯作者：
Pecoraro, Norman C.
中科院分区：
文献类型：
--
作者：
Dallman, Mary F.;Warne, James P.;Pecoraro, Norman C.
糖皮质激素主要以前馈的方式作用于大脑，以激活CNS通路，实现适合生理需要的需求。因此，根据可用的条件，糖皮质激素升高可能会增加奔跑、战斗或进食的行为需求。虽然糖皮质激素刺激食物、脂肪和蔗糖的摄入，但胰岛素似乎通过迷走神经的肝分支传入作用，塑造对高脂肪食物的热量相关欲望。食物供给减少和慢性压力都会刺激糖皮质激素增强的中枢神经网络，从而导致最终的腹部肥胖。
Glucocorticoids act primarily in a feed-forward fashion on brain to activate CNS pathways that implement wanting appropriate to physiological needs. Thus, depending on the available conditions, elevated glucocorticoids may augment the behavioural want to run, fight or feed. Although glucocorticoids stimulate intake of chow, fat and sucrose, insulin appears to sculpt calorie-associated desires toward foods high in fat, acting through hepatic branch afferents of the vagus nerve. Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity.