Comparative analysis of staphylococcal adhesion and internalization by epithelial cells.
Comparative analysis of staphylococcal adhesion and internalization by epithelial cells.
复制标题
葡萄球菌粘附和上皮细胞内化的比较分析。
DOI：
10.1007/978-1-59745-468-1_11
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Ji,Yinduo
中科院分区：
文献类型：
--
作者：
Liang,Xudong;Ji,Yinduo
对抗生素的多重耐药性是一个主要的公共卫生问题。许多机制可能涉及这种阻力。越来越多的数据表明，金黄色葡萄球菌可以侵入不同类型的非吞噬细胞，这反过来可能有助于逃避某些抗生素的毒性。纤连蛋白结合蛋白是S.金黄色粘附并内化到宿主细胞中。我们已经表明，一个双组分的信号转导系统，SaeRS，是必不可少的细菌粘附和入侵的上皮细胞。
Multiple drug resistance to antibiotics is a major public health problem. Many mechanisms may be involved in such resistance. Increasing data have shown thatStaphylococcus aureuscan invade different types of nonphagocytic cells, which, in turn, may contribute to evasion of the toxicity of certain antibiotics. The fibronectin-binding proteins are required forS. aureusto adhere to and internalize into the host cells. We have shown that a two-component signal transduction system, SaeRS, is essential for bacterial adhesion and invasion of the epithelial cells.