Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.
Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.
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发表时间：
1989-02
期刊：
影响因子：
11.2
通讯作者：
L. B. Kinsel;E. Szabo;G. Greene;J. Konrath;G. Leight;K. Mccarty
中科院分区：
文献类型：
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作者：
L. B. Kinsel;E. Szabo;G. Greene;J. Konrath;G. Leight;K. Mccarty
雌激素受体的生化定量已被用于预测乳腺癌的预后。雌激素受体的免疫细胞化学分析与生化分析相关，但文献中很少有后续研究证实其作为预后指标。257例患者在初次手术治疗后随访10年（中位6.2年）。用生化和免疫细胞化学技术对肿瘤标本进行雌激素受体分析。雌激素受体阳性患者的生存期长于阴性患者。在前5年的随访中，这两种方法都证明了这一点，但在5年后，只有免疫化学才能证明这一点。雌激素受体状态与无病间隔的关系不如与生存的关系强。本研究表明免疫细胞化学雌激素受体分析具有预后意义。
Biochemical quantitation of estrogen receptors has been used to predict prognosis in breast cancer. Immunocytochemical analysis of estrogen receptors correlates with biochemical analysis but has very few follow-up studies in the literature to validate it as a prognostic indicator. 257 patients were followed for up to 10 years (median, 6.2 years) after primary surgical treatment. Estrogen receptor analysis using both biochemical and immunocytochemical techniques was performed on their tumor specimens. Patients with positive estrogen receptor values had longer survival than patients with negative values. This was demonstrated by both methods in the first 5 years of follow-up but only by immunochemistry after 5 years. The relationship between estrogen receptor status and disease-free interval was less strong than with survival. This study demonstrates that immunocytochemical estrogen receptor analysis was of prognostic significance.