The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7.

The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7.
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大鼠 MIS1/Pvt-1 基因座与 7 号染色体上的 MYC 同线。

DOI:
10.1159/000132450
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发表时间:
1987
期刊:
Cytogenetics and cell genetics
影响因子:
--
通讯作者:
Sümegi,J
Sümegi,J
中科院分区:
--
文献类型:
--
作者:
Ingvarsson,S;Wirschubsky,Z;Szpirer,J;Levan,G;Klein,G;Sümegi,J

文献摘要

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相似文献

小鼠Pvt-1和大鼠MIS1是逆转录病毒诱导的淋巴瘤中常见的前病毒整合位点。 Pvt-1 位点还涉及小鼠浆细胞瘤 (6;15) 和变异型伯基特淋巴瘤 (2;8) 易位。我们表明Pvt-1/MIS1基因座与大鼠7号染色体上的MYC同线。这与密切连锁的假设一致,并且可能与MYC原子同基因和MIS1/Pvt-1基因座之间的功能关系一致。
MousePvt-1and rat MISl are frequent proviral integration sites in retrovirally induced lymphomas. ThePvt-1locus is also involved in mouse plasmacytoma (6;15) and in the variant Burkitt lymphoma (2;8) translocations. We show that the Pvt-1/MISl locus is syntenic with MYC on rat chromosome 7. This is consistent with a postulate of close linkage and, possibly, a functional relationship between the MYC protoon-cogene and the MIS1/Pvt-1 locus.