Levothyroxine replacement dose for primary hypothyroidism decreases with age.
Levothyroxine replacement dose for primary hypothyroidism decreases with age.
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原发性甲状腺功能减退症的左旋甲状腺素替代剂量随着年龄的增长而减少。
DOI：
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发表时间：
1982
影响因子：
39.2
通讯作者：
U. Barzel
中科院分区：
文献类型：
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作者：
R. L. Rosenbaum;U. Barzel
我们研究了23例老年（65岁以上）和44例年轻的原发性甲状腺功能减退症患者，以确定与年龄有关的完全替代所需的左旋甲状腺素剂量。老年患者（平均年龄，75.7岁）需要平均118微克/天，而年轻患者（平均年龄，48.1岁）需要158微克/天。这些数据表明，甲状腺素的需求量可能会随着年龄的增长而持续下降。这种降低可能反映了甲状腺素降解率随年龄增长而逐渐降低。
We studied 23 elderly (other than 65) and 44 younger ambulatory adult patients with primary hypothyroidism to ascertain the dose of levothyroxine needed for complete replacement in relation to age. The elderly patients (average age, 75.7 years) needed an average 118 microgram/d whereas the younger patients (average age, 48.1 years) needed 158 microgram/d. The data indicate that thyroxine requirement may decrease continuously with age. This decrease probably reflects the progressive decrease in thyroxine degradation rate that occurs with age.