The Limitation of Evaluating Cingulate Island Sign by SPECT
The Limitation of Evaluating Cingulate Island Sign by SPECT
复制标题
SPECT评估扣带岛征的局限性
DOI：
10.1093/jnen/nlz109
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Iizuka T
中科院分区：
文献类型：
--
作者：
Kameyama M;Iizuka T
扣带回岛征(CIS)是指后扣带回皮质(PCC)代谢相对较少，是区分路易体痴呆(DLB)和阿尔茨海默病(AD)的重要生物标志物。CIS的潜在基础尚不清楚；因此，我们的目的是调查哪些神经退行性变化支撑了CIS的形成。应用定量神经病理学方法，对12例DLB、9例AD和6例年龄匹配的对照组的前扣带回、中扣带回、扣带回、楔前/楔前回和海马旁回的α-突触核蛋白、磷酸化Tau和淀粉样蛋白-β的病理变化进行了研究。所有参与者在生前都接受了99mTC-六亚甲基丙基丙胺肟(HMPAO)单光子发射计算机断层扫描，以确定是否存在CIS。在DLB组中，PCC的CIS比率与神经退行性病变之间没有明显的相关性。然而，在DLB中，与PCC相比，ACC显示更低的HMPAo摄取，以及显著更高的α-突触核蛋白和淀粉样蛋白-β负荷，这可能是PCC与ACC相比相对保存灌流的原因。我们的研究结果表明，神经退行性病变与DLB中的CIS没有直接的相关性，因此其他代谢或病理变化更有可能与CIS的发展有关。
The cingulate island sign (CIS) refers to the relative sparing of metabolism in the posterior cingulate cortex (PCC) and represents an important biomarker in distinguishing dementia with Lewy bodies (DLB) from Alzheimer disease (AD). The underlying basis of the CIS is unknown; therefore, our aim was to investigate which neurodegenerative changes underpin the formation of CIS. Using quantitative neuropathology, α-synuclein, phosphorylated Tau, and amyloid-β pathology was assessed in 12 DLB, 9 AD and 6 age-matched control patients in the anterior cingulate (ACC), midcingulate, PCC, precuneus/cuneus and parahippocampal gyrus. All participants had undergone99mTc-hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography imaging during life to define the presence or absence of CIS. In the DLB group, no significant correlations were observed between CIS ratios and neurodegenerative pathology in PCC. In DLB, however, the ACC showed lower HMPAO uptake, as well as significantly higher α-synuclein and amyloid-β burden compared with PCC, possibly underlying the relative preservation of perfusion in PCC when compared with ACC. Our findings suggest that neurodegenerative pathology does not directly correlate with the CIS in DLB, and other metabolic or pathological changes are therefore more likely to be relevant for the development of the CIS.