Functional Magnetic Resonance Imaging of Working Memory and Response Inhibition in Children with Mild Traumatic Brain Injury
Functional Magnetic Resonance Imaging of Working Memory and Response Inhibition in Children with Mild Traumatic Brain Injury
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DOI：
10.1017/s1355617711001226
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发表时间：
2011-11-01
影响因子：
2.6
通讯作者：
Gioia, Gerard
中科院分区：
文献类型：
--
作者：
Krivitzky, Lauren S.;Roebuck-Spencer, Tresa M.;Gioia, Gerard
目前的试点研究检查了轻度创伤性脑损伤 (mTBI) 儿童在工作记忆和抑制控制任务期间的功能磁共振成像 (fMRI) 激活情况，这两项任务在 mTBI 后都很容易受到损害。 13 名患有 mTBI 症状的儿童和一组对照组在功能磁共振成像扫描期间完成了执行控制任务 (TEC) 的一个版本。两组人都表现出更大的前额叶激活以应对工作记忆负荷的增加。在任务的工作记忆方面，各组之间的激活模式没有差异，但患有 mTBI 的儿童在小脑后部表现出更大的激活，并且增加了抑制控制的需求。患有 mTBI 的儿童在症状报告和执行功能的“现实世界”测量方面表现出更大的障碍，但在传统的“纸和铅笔”任务方面则没有。同样，认知测试与影像学结果没有显着相关性，而脑震荡后症状报告的增加与小脑激活的增加相关。总体而言，结果提供了一些证据，证明症状报告作为恢复指标的实用性，以及患有 mTBI 的儿童在恢复过程中可能会经历神经回路中断的假设。该研究的局限性包括样本量小、年龄范围宽以及缺乏扫描仪内的准确性数据。 (JINS, 2011, 17, 1143-1152)
The current pilot study examined functional magnetic resonance imaging (fMRI) activation in children with mild traumatic brain injury (mTBI) during tasks of working memory and inhibitory control, both of which are vulnerable to impairment following mTBI. Thirteen children with symptomatic mTBI and a group of controls completed a version of the Tasks of Executive Control (TEC) during fMRI scanning. Both groups showed greater prefrontal activation in response to increased working memory load. Activation patterns did not differ between groups on the working memory aspects of the task, but children with mTBI showed greater activation in the posterior cerebellum with the addition of a demand for inhibitory control. Children with mTBI showed greater impairment on symptom report and "real world'' measures of executive functioning, but not on traditional "paper and pencil'' tasks. Likewise, cognitive testing did not correlate significantly with imaging results, whereas increased report of post-concussive symptoms were correlated with increased cerebellar activation. Overall, results provide some evidence for the utility of symptom report as an indicator of recovery and the hypothesis that children with mTBI may experience disrupted neural circuitry during recovery. Limitations of the study included a small sample size, wide age range, and lack of in-scanner accuracy data. (JINS, 2011, 17, 1143-1152)