MicroRNAs
MicroRNAs
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DOI：
10.1097/ppo.0b013e318164145e
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发表时间：
2008-01-01
期刊：
影响因子：
2.2
通讯作者：
Calin, George A.
中科院分区：
文献类型：
--
作者：
Fabbri, Muller;Croce, Carlo M.;Calin, George A.
microRNAs（miRNAs）是一类具有调控功能的非编码小RNA，在包括癌症在内的多种人类疾病中发挥重要作用。越来越多的研究表明，miRNAs既可以作为癌基因，也可以作为肿瘤抑制基因，有时两者兼而有之。生殖系、体细胞突变和多态性可导致癌症易感性。miRNA表达水平具有诊断和预后意义，其作为抗癌治疗剂的作用是有希望的，目前正在研究中。
MicroRNAs (miRNAs) are small, noncoding RNAs with regulatory functions, which play an important role in many human diseases, including cancer. An emerging number of studies show that miRNAs can act either as oncogenes or as tumor suppressor genes or sometimes as both. Germline, somatic mutations and polymorphisms can contribute to cancer predisposition. miRNA expression levels have diagnostic and prognostic implications, and their roles as anticancer therapeutic agents is promising and currently under investigation.