Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review.
Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review.
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DOI：
10.1089/photob.2018.4604
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发表时间：
2019-07
期刊：
影响因子：
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通讯作者：
Noemi Vanerio;M. Stijnen;B. D. de Mol;L. Kock
中科院分区：
文献类型：
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作者：
Noemi Vanerio;M. Stijnen;B. D. de Mol;L. Kock
目的：本综述的目的是讨论和比较广泛的生物医学应用的光和声激活虎红（RB）。背景资料：RB是一种氧杂蒽染料，由于其有趣的光和声敏特性，在科学领域受到关注。方法：本研究使用PubMed数据库进行文献综述。结果：RB作为光敏剂，在绿色光（532 nm）照射下，将三重态氧分子转化为活性氧。该机制允许光活化RB用于光化学组织结合、光动力疗法、抗微生物疗法和癌症治疗、光血栓形成动物模型和其他应用，包括组织工程和tau蛋白病的治疗。RB作为一种声敏化合物，被应用于声动力学治疗、癌症治疗和抗菌治疗。结论：本文综述了光和声激活RB在许多生物医学应用中的多功能性和有效性。
Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.