Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.
Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.
复制标题
DOI：
10.1007/s00395-015-0527-0
复制
发表时间：
2016-01
影响因子：
9.5
通讯作者：
Hausenloy DJ
中科院分区：
文献类型：
--
作者：
Cabrera-Fuentes HA;Alba-Alba C;Aragones J;Bernhagen J;Boisvert WA;Bøtker HE;Cesarman-Maus G;Fleming I;Garcia-Dorado D;Lecour S;Liehn E;Marber MS;Marina N;Mayr M;Perez-Mendez O;Miura T;Ruiz-Meana M;Salinas-Estefanon EM;Ong SB;Schnittler HJ;Sanchez-Vega JT;Sumoza-Toledo A;Vogel CW;Yarullina D;Yellon DM;Preissner KT;Hausenloy DJ
心血管基础研究的最新进展及其临床应用是上一届“心血管研究的新前沿”会议的焦点。主要主题包括表征心脏保护的新靶点和程序，破译缺血性心脏病的新参与者和炎症机制，以及揭示microRNAs和其他生物标记物在心血管发病机制中的多功能和可能的因果因素。虽然可以在不同的动物模型中模拟和操纵一些病理情况，如缺血再灌注损伤或动脉粥样硬化，也可以挑战用于干预的新药，但患者研究是获得关于生物医学概念的有效性及其在临床上应用的明确信息的最终试金石。因此，板凳和床边之间的开放和双向交流对于推动缺血性心脏病领域的发展至关重要，尤其强调了解心脏保护的长期方法。
Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last “New Frontiers in Cardiovascular Research meeting”. Major topics included the characterization of new targets and procedures in cardioprotection, deciphering new players and inflammatory mechanisms in ischemic heart disease as well as uncovering microRNAs and other biomarkers as versatile and possibly causal factors in cardiovascular pathogenesis. Although a number of pathological situations such as ischemia–reperfusion injury or atherosclerosis can be simulated and manipulated in diverse animal models, also to challenge new drugs for intervention, patient studies are the ultimate litmus test to obtain unequivocal information about the validity of biomedical concepts and their application in the clinics. Thus, the open and bidirectional exchange between bench and bedside is crucial to advance the field of ischemic heart disease with a particular emphasis of understanding long-lasting approaches in cardioprotection.