Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro-magnetic tissue properties study group
Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro-magnetic tissue properties study group
复制标题
DOI：
10.1002/mrm.30006
复制
发表时间：
2024-01-21
影响因子：
3.3
通讯作者：
Wang，Yi
中科院分区：
文献类型：
--
作者：
Bilgic，Berkin;Costagli，Mauro;Wang，Yi
本文提出了在临床脑研究中实施QSM的建议。这是国际磁共振医学学会电磁组织特性研究组的共识。随着QSM技术的不断发展，目前的QSM方法已经被证明是可重复和可再现的，可以在大脑中生成定量的组织磁化率图。然而，许多可用的QSM方法已经在神经影像学社区产生了对实施指南的需求。本文概述了QSM数据获取、处理、分析和发布的注意事项和实现建议。我们建议使用单极三维多回波梯度回波（GRE）序列获取数据，并将相位图像保存并导出为医学数字成像和通信（DICOM）格式，并使用精确的解包裹方法展开。在去除背景场之前，应合并多回波图像，并使用脑提取工具创建脑掩膜，并结合基于相位质量的掩膜。脑掩膜内的背景场应使用基于SHARP或PDF的技术去除，偶极子反演的优化方法应采用基于稀疏度的正则化。敏感性值应该相对于一个特定的参考来测量，包括整个大脑的共同参考区域作为分析的兴趣区域。还提供了报告QSM结果时所需的最小获取和处理细节。这些建议应有助于临床QSM研究，并促进数据采集、分析和报告的统一。
This article provides recommendations for implementing QSM for clinical brain research. It is a consensus of the International Society of Magnetic Resonance in Medicine, Electro‐Magnetic Tissue Properties Study Group. While QSM technical development continues to advance rapidly, the current QSM methods have been demonstrated to be repeatable and reproducible for generating quantitative tissue magnetic susceptibility maps in the brain. However, the many QSM approaches available have generated a need in the neuroimaging community for guidelines on implementation. This article outlines considerations and implementation recommendations for QSM data acquisition, processing, analysis, and publication. We recommend that data be acquired using a monopolar 3D multi‐echo gradient echo (GRE) sequence and that phase images be saved and exported in Digital Imaging and Communications in Medicine (DICOM) format and unwrapped using an exact unwrapping approach. Multi‐echo images should be combined before background field removal, and a brain mask created using a brain extraction tool with the incorporation of phase‐quality‐based masking. Background fields within the brain mask should be removed using a technique based on SHARP or PDF, and the optimization approach to dipole inversion should be employed with a sparsity‐based regularization. Susceptibility values should be measured relative to a specified reference, including the common reference region of the whole brain as a region of interest in the analysis. The minimum acquisition and processing details required when reporting QSM results are also provided. These recommendations should facilitate clinical QSM research and promote harmonized data acquisition, analysis, and reporting.