DDIT3 overexpression increases odontoblastic potential of human dental pulp cells
DDIT3 overexpression increases odontoblastic potential of human dental pulp cells
复制标题
DOI：
10.1111/cpr.12104
复制
发表时间：
2014-06
影响因子：
8.5
通讯作者：
Y. Wu;H. Sun;F. Song;D. Fu;J. Wang
中科院分区：
文献类型：
--
作者：
Y. Wu;H. Sun;F. Song;D. Fu;J. Wang
具有多向分化潜能的人牙髓细胞（HDPC）在促炎细胞因子刺激下可向成牙本质细胞分化。然而，促炎刺激和成牙本质细胞分化的相关因素尚未完全了解。DDIT 3作为一种凋亡转录因子，在炎症反应和成骨分化中起着至关重要的作用。因此，我们推测DDIT 3可能参与HDPC的成牙本质细胞分化。
Human dental pulp cells (HDPCs) with multi‐potential differentiational capacity can undergo odontoblastic differentiation when stimulated with proinflammatory cytokines. However, factors linking proinflammatory stimuli and their odontoblastic differentiation have, as yet, not been completely understood. As an apoptotic transcription factor, DDIT3 plays a crucial role in the inflammatory reaction and in osteogenic differentiation. Thus, we hypothesized that DDIT3 may participate in odontoblastic differentiation of HDPCs.