Investigative use of bronchoscopy in asthma
Investigative use of bronchoscopy in asthma
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DOI：
10.1164/ajrccm.157.3.9705020
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发表时间：
1998-03-01
影响因子：
24.7
通讯作者：
Calhoun, WJ
中科院分区：
文献类型：
--
作者：
Jarjour, NN;Peters, SP;Calhoun, WJ
在20世纪70年代早期，Reynolds和Newball（1）是最早报道他们使用纤维支气管镜和“支气管”（支气管肺泡）灌洗（BAL）的经验的人之一，目的是从人类志愿者中获得呼吸细胞和分泌物用于体外分析。然而，直到大约10年后，才开始在哮喘受试者中进行研究（2）。此后，使用支气管镜检查和各种支气管镜技术进行了数百项研究（部分综述见参考文献3）。这些研究证明了气道炎症在哮喘中的重要性（4），即使在轻度疾病患者中也是如此，并支持在哮喘中推荐使用抗哮喘药物（5）。在这篇综述中，我们总结了有关支气管镜在哮喘中的研究性应用的信息，特别强调了BAL、抗原激发、支气管内活检和支气管刷检的方法、安全性和实用性。
In the early 1970s, Reynolds and Newball (1) were among the first to report their experience with fiberoptic bronchoscopy and “bronchial”(bronchoalveolar) lavage (BAL) in order to obtain respiratory cells and secretions from human volunteers for in vitro analysis. However, it was not until approximately 10 years later that studies were initiated in subjects with asthma (2). Since then hundreds of studies have been done using bronchoscopy and various bronchoscopic techniques (reviewed in part in reference 3). These investigations demonstrated the importance of airway inflammation in asthma (4), even in patients with mild disease, and supported the recommended use of antiinflammatory medications in asthma (5). In this review, we summarize information concerning the investigative use of bronchoscopy in asthma, with special emphasis on the methods, safety, and utility of BAL, antigen challenge, endobronchial biopsies, and bronchial brushing.