Neutrophils in periodontal inflammation.
Neutrophils in periodontal inflammation.
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DOI：
10.1159/000329672
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Krauss J
中科院分区：
文献类型：
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作者：
Scott DA;Krauss J
中性粒细胞是最丰富的白细胞，是骨髓来源的专业抗微生物吞噬细胞，也可以在细胞外杀死病原体，连接免疫反应的先天和适应性臂，并帮助促进炎症消退和组织愈合。中性粒细胞广泛存在于龈沟和上皮中，被认为是牙周组织中的关键保护细胞类型（1-4）。有趣的是，组织学证据（见图1）表明中性粒细胞在结合上皮和富含病原体的牙菌斑之间形成了一堵“墙”（2-3）。提供不仅仅是屏障功能，这种抗菌壁被认为以两种方式起作用：作为一个强大的分泌结构（活性氧[ROS]和杀菌蛋白）和作为一个统一的吞噬装置。换句话说，保护力在于协同结构。然而，这种保护并非没有代价，因为大量的观察、遗传和实验数据已经确立了中性粒细胞浸润到牙周组织中与炎性牙周病的严重程度和进展之间的明确关联（3，5-7）。
Neutrophils, the most abundant of the leukocytes, are myeloid-derived, professional antimicrobial phagocytes that can also kill pathogens extracellularly, link the innate and adaptive arms of the immune response, and help promote inflammatory resolution and tissue healing. Found extensively within the gingival crevice and epithelium, neutrophils are considered the key protective cell type in the periodontal tissues (1–4). Intriguingly, histological evidence (see Figure 1) suggesting that neutrophils form a “wall” between the junctional epithelium and the pathogen-rich dental plaque (2–3). Providing more than a mere barrier function, this antimicrobial wall is thought to function in two ways: as a robust secretory structure (reactive oxygen species [ROS] and bacteriocidal proteins) and as a unified phagocytic apparatus. In other words, the protective power lies in the synergic structure. However, this protection is not without cost as considerable observational, genetic and experimental data have established a clear association between neutrophil infiltration into the periodontal tissues and the severity and progression of inflammatory periodontal diseases (3, 5–7).