Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.
Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14.
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糟糕的开始：多能性调节剂 PRDM14 引发癌症。
DOI：
10.1016/j.tig.2019.04.004
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Justice,MonicaJ
中科院分区：
文献类型：
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作者：
Tracey,LaurenJ;Justice,MonicaJ
尽管化学疗法在提高癌症生存率方面取得了进展，但大多数复发的患者还是因癌症干细胞（CSC）的存在而死亡，而癌症干细胞具有高度的化学抗性。多能因子 PR 结构域 14 (PRDM14) 在多种癌症的引发中发挥着关键作用。通常，PRDM14利用表观遗传机制来建立和维持胚胎细胞的多能性，其在癌症中的作用类似。癌症与诱导多能性之间的这一重要联系是 CSC 如何形成的关键启示：多能性基因（例如 PRDM14）可以在促进持续的 DNA 损伤时扩增干细胞样细胞。 PRDM14 及其蛋白结合伴侣 ETO/CBFA2T 家族是消除相关癌症中的 CSC、预防复发和提高长期生存率的理想候选者。
Despite advances in chemotherapies that improve cancer survival, most patients who relapse succumb to the disease due to the presence of cancer stem cells (CSCs), which are highly chemoresistant. The pluripotency factor PR domain 14 (PRDM14) has a key role in initiating many types of cancer. Normally, PRDM14 uses epigenetic mechanisms to establish and maintain the pluripotency of embryonic cells, and its role in cancer is similar. This important link between cancer and induced pluripotency is a key revelation for how CSCs may form: pluripotency genes, such asPRDM14, can expand stem-like cells as they promote ongoing DNA damage. PRDM14 and its protein-binding partners, the ETO/CBFA2T family, are ideal candidates for eliminating CSCs from relevant cancers, preventing relapse and improving long-term survival.