Apoptosis following Gamma Knife Radiosurgery in a Case of Acoustic Schwannoma
Apoptosis following Gamma Knife Radiosurgery in a Case of Acoustic Schwannoma
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听神经鞘瘤伽玛刀放射外科治疗后的细胞凋亡
DOI：
10.1159/000056411
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发表时间：
1998
影响因子：
1.7
通讯作者：
F. Ikawa
中科院分区：
文献类型：
--
作者：
S. Fukuoka;K. Oka;Y. Seo;M. Tokanoshi;Y. Sumi;Hirohiko Nakamura;J. Nakamura;F. Ikawa
一名25岁的女性，患有巨大的听神经鞘瘤，在伽玛刀放射外科手术后18个月因肿瘤短暂扩张引起共济失调而接受手术切除。TUNEL法的组织学研究显示存在一些凋亡细胞。结果进行了比较，结果从7个手术病例的对照组，其中没有使用放射外科。在这些病例中均未发现细胞凋亡。此外，另一例伽玛刀治疗后肿瘤再生长的病例也未显示细胞凋亡。这些发现表明细胞凋亡可能是伽玛刀治疗后肿瘤缩小的一种可能机制。
A 25-year-old woman with a large acoustic schwannoma underwent surgical excision 18 months after Gamma Knife radiosurgery because of transient expansion of the tumor causing ataxia. Histopathologial investigation by the TUNEL method revealed the presence of some apoptotic cells. The findings were compared with findings from a control group of 7 operated cases where radiosurgery had not been used. There was no apoptosis found in any of these cases. In addition, another case which resulted in a regrowing tumor following Gamma Knife treatment also showed no apoptosis. These findings suggest apoptosis may be a possible mechanism in reducing tumor size following Gamma Knife radiosurgery.