SMPDL3A links cholesterol metabolism to the cGAS-STING pathway.
SMPDL3A links cholesterol metabolism to the cGAS-STING pathway.
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SMPDL3A 将胆固醇代谢与 cGAS-STING 通路联系起来。
DOI：
10.1016/j.immuni.2023.10.015
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发表时间：
2023
期刊：
影响因子：
32.4
通讯作者：
Chung,Hachung
中科院分区：
文献类型：
--
作者：
Shin,Heegwon;Chung,Hachung
肝脏 X 受体 (LXR) 以其在胆固醇代谢中的作用而闻名，也具有抗炎特性。在本期《免疫》中，Hou 等人。证明 LXR 信号传导诱导 SMPDL3A，这是一种限制 cGAS-cGAMP-STING 先天免疫信号传导的 cGAMP 降解酶，提供脂质代谢和炎症之间的机制联系。
Liver X receptor (LXR), well known for its role in cholesterol metabolism, also has anti-inflammatory properties. In this issue ofImmunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune signaling, providing a mechanistic link between lipid metabolism and inflammation.