ESTABLISHING AEROSOL EXPOSURE CONCENTRATIONS FOR INHALATION TOXICITY STUDIES
ESTABLISHING AEROSOL EXPOSURE CONCENTRATIONS FOR INHALATION TOXICITY STUDIES
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DOI：
10.1016/0041-008x(89)90147-6
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发表时间：
1989-07-01
影响因子：
3.8
通讯作者：
CHHABRA, RS
中科院分区：
文献类型：
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作者：
LEWIS, TR;MORROW, PE;CHHABRA, RS
在国家毒理学计划主办的一次会议上，作者讨论了用于评估化学物质的毒性和致癌性的吸入研究中使用的气溶胶浓度的选择标准。气溶胶吸入研究设计的概念产生于那次会议，并通过本出版物进行交流。评估气溶胶的毒性和致癌性的吸入研究通常在技术可行性的基础上使用最大暴露水平。目前积累的证据表明，在某些尚未明确定义的暴露浓度之上，沉积颗粒的肺负荷量会对颗粒清除产生影响。其后遗症是肺清除率随着颗粒物负荷的增加而降低，直至接近完全戒烟。本文重点介绍了用于吸入毒性研究的最大气溶胶浓度的主要决定因素，特别强调了评估肺潴留的实验设计特征。本文的主题是一个在知识方面迅速发展的领域。因此，本文的内容旨在作为指导方针，而不是作为进行和解释吸入暴露研究的绝对规则。
Criteria for the selection of aerosol concentrations to be used in inhalation studies assessing the toxicity and carcinogenicity of chemical substances were discussed by the authors in a meeting sponsored by the National Toxicology Program. Concepts in the design of aerosol inhalation studies emerged from that meeting and are being communicated through this publication. Inhalation studies assessing the toxicity and carcinogenicity of aerosols have often used maximum exposure levels on the basis of technological feasibility. Evidence has now accumulated that the amount of pulmonary burden of deposited particles impacts on particle clearance above some as yet not well-defined exposure concentration. The sequelae are such that lung clearance decreases with increased particulate burden to the point of approaching complete cessation. This paper focuses on the major determinants in establishing maximal aerosol concentrations for use in inhalation toxicity studies with special emphasis on experimental design features to assess lung retention. The subject matter of this paper is a rapidly developing area in terms of knowledge. Accordingly, the contents of this article are intended as guidelines and not as absolute rules for the conduct and interpretation of inhalation exposure studies.