Risk of cognitive decline in older patients after carotid endarterectomy: An observational study
Risk of cognitive decline in older patients after carotid endarterectomy: An observational study
复制标题
DOI：
10.1111/j.1532-5415.2006.00787.x
复制
发表时间：
2006-06-01
影响因子：
6.3
通讯作者：
Poli, Leone
中科院分区：
文献类型：
--
作者：
Bo, Mario;Massaia, Massimiliano;Poli, Leone
目的：为了确定有症状的左颈内动脉（LICA）狭窄患者接受颈动脉内膜切除术（CE）是否比无症状的LICA疾病或右颈内动脉（RICA）疾病患者有更大的认知能力下降的风险。设计：观察。该分析包括103名患者（平均年龄72.6 ± 7.0，73名男性），其中50名患有LICA疾病（29例有症状）。认知功能评价（年龄和教育调整的简易精神状态检查（MMSE），时钟测试（CLOX 1和2））在基线和研究期结束时（平均随访+/-标准差44.4 +/- 14.3个月），样本年龄65岁及以上，无认知功能障碍，连续接受CE检查。在研究结束时，有症状的LICA疾病患者的MMSE、CLOX 1和CLOX 2评分显著降低（P
OBJECTIVES: To determine whether patients undergoing carotid endarterectomy (CE) for symptomatic left internal carotid artery (LICA) stenosis have greater risk of cognitive decline than patients with asymptomatic LICA disease or right internal carotid artery (RICA) disease.DESIGN: Observational.SETTING: Vascular surgery day hospital.PARTICIPANTS: The analysis included 103 patients (mean age 72.6 +/- 7.0, 73 men), of whom 50 had LICA disease (29 symptomatic).MEASUREMENTS: Cognitive function was evaluated (age- and education-adjusted Mini-Mental State Examination (MMSE), and Clock tests (CLOX1 and 2)) at baseline and at the end of the study period (average follow-up +/- standard deviation 44.4 +/- 14.3 months) in a sample of patients aged 65 and older, free from cognitive impairment, consecutively undergoing CE.RESULTS: At the end of the study period, MMSE, CLOX1, and CLOX2 scores were significantly lower in patients with symptomatic LICA disease (P